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The intravenously administered macrocylic peptidomimetic molecule ulimorelin, enhanced gastric emptying, and was subsequently mainly studied in critical care patients, with lack of differentiation from metoclopramide ( Motilin Motilin is released from M-cells situated in the proximal duodenum during the fasted state, is a stimulus for strong antral contractions and has a hunger signaling function ( In patients with FD and delayed gastric emptying, motilin plasma levels did not display the normal fluctuations during the interdigestive state and gastric phase III contractions were absent ( Several macrolide antibiotics such as erythromycin and azithromycin have motilin receptor agonistic effects, and have a stimulatory effect on gastric emptying rate ( Camicinal is a novel small molecule motilin receptor agonist with short half-life, which was shown to induce gastric phase III contractions during the fasting state and dose-dependently enhance gastric emptying rate ( Cholecystokinin (CCK) CCK is a brain-gut peptide released from I-cells in the upper small intestine upon food intake, especially after meals containing high fat or protein amounts ( H
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