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In 2024 the journal Diabetes named it as a classic paper
For example, GLP-1R/GIPR dual agonists have demonstrated superior glucose-lowering and weight-loss effects in the treatment of diabetes and obesity
J Clin Invest 133(3):e167952 [DOI] [PMC free article] [PubMed] [Google Scholar] 16.Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs
(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1
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