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4 Liraglutide currently is the sole GLP-1 agonist studied for treating SGA-associated weight gain

Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sanchdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT (2005) Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension and mortality in sickle cell disease

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The N,N,N-trimethyllysine-associated proteins ACSS1 (acyl-CoA synthetase short-chain family member 1) and ACSF2 (acyl-CoA synthetase family member 2) are key enzymes involved in fatty acid metabolism and energy production

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1 CVS says the change is intended to improve affordability and expand treatment options for employers offering GLP-1 coverage