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As research continues, we'll learn even more about how these medications work and who they can help

Intravenous administration results in even more rapid excretion with little opportunity for liver storage

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However, evidence-based algorithms guiding when and how to initiate GLP-1 RAs postoperatively are currently lacking

Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]

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