NICE has appraised its use within specialist weight management services, subject to BMI and eligibility criteria [12] Liraglutide (Saxenda) another licensed GLP-1 receptor agonist available for weight management in adults, subject to MHRA-approved indications and prescribing criteria Orlistat (Xenical/Alli) a lipase inhibitor available on NHS prescription and, at lower dose, over the counter Tirzepatide (Zepbound) a dual GIP/GLP-1 receptor agonist authorised by the MHRA specifically for chronic weight management in adults
Most importantly, the effects of GLP-1RAs are not consistent 28
Some patients find side effects intolerable and discontinue treatment
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Solution: When less than 2 doses remain in a vial, consider starting a new vial for consistency
If a deficiency is confirmed, licensed recombinant human growth hormone therapy (somatropin) may be considered under specialist supervision in accordance with NICE guidance