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(PDF) Abbreviations 5,10-methyleneTHF: 5,10-methylenetetrahydrofolate THF: tetrahydrofolate DHF: dihydrofolate dUMP: deoxyuridine monophosphate dTMP: deoxythymine monophosphate 5-methylTHF: 5-methyltetrahydrofolate cSHMT: cytosolic serinehydroxymethyl transferase mSHMT: mitochondrial serinehydroxymethyl transferase MTHFR: methylenetetrahydrofolate reductase TYMS: thymidylate synthase DHFR: dihydrofolate reductase Declarations Conflict of interest The authors have no conflict of interests related to this publication
Daver NG, Pollyea DA, Garcia JS, Jonas BA, Yee KWL, Fenaux P, Assouline S, Vey N, Olin R, Roboz GJ, Tafuri A, Visani G, Kirschbrown W, Green C, Ma C, Dail M, Wang J, Ott MG, Mobasher M, Phuong P, Hong WJ, Konopleva MY, Andreeff M
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The reduction in hepatic fat in HIV-associated fatty liver disease, alongside the primary visceral-fat effect, has been characterized in randomized trials, and the mechanistic follow-up identified reductions in fibro-inflammatory mediators (VEGFA, TGF-1, CSF1) that track with improvements in liver-injury scores
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