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placebo) Change in WOMAC pain subscale score: -4.0 points (-67.2%

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Although fixed-ratio combination therapies maintain a constant GLP-1 RA-to-basal insulin ratio, individualized titration remains a challenge, potentially leading to excess or deficiency of either component

Medication-Specific Factors: Type of GLP-1 agonist : Newer agents like semaglutide tend to be more expensive than older formulations such as exenatide, though they may offer once-weekly convenience versus twice-daily dosing