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These nanoparticles can pass through paracellular transport, damage the tight junction proteins, activate the immune system, and contribute to disease pathogenesis

2017 The 2017 study by Tang, Podratz, Lange et al

While their full MoA remains to be elucidated, it is known that they can activate Nrf2

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JCI Insight 8 , e160516 (2023)