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Constipation: This is reported slightly more often with semaglutide, at 29% versus 27% with tirzepatide

Saxagliptin was previously shown to inhibit the AngII-induced activation of a range of cardiac proinflammatory/profibrotic signaling intermediates, including interleukin 18 (IL-18), interleukin 17A (IL-17A), nuclear transcription factor-B (NF-B), and TLR4 (39)

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