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This is because semaglutide is a so-called GLP-1 receptor agonist

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We don't yet know. A range of autoimmune diseases that affect various organ systems and cause muscle wasting may be good candidates (mouse and preliminary human studies suggest) for GLP-1 receptor agonist treatment because of their ability to reduce the expression and release of inflammatory cytokines

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Therefore, they may choose to maintain a lower dose if it causes fewer gastrointestinal symptoms