These data demonstrate that deletion of the GCLC protein can be induced in the liver of adult animals
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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104
DiNardo CD, Verma D, Baran N, Bhagat TD,Skwarska A,Lodi A,Saxena K,Cai T,Su X,Guerra VA,Poigaialwar G, Kuruvilla VM, Konoplev S, Gordon-Mitchell S, Pradhan K, Aluri S,Hackman GL,Chaudhry S,Collins M,Sweeney SR,Busquets J,Rathore AS,Deng Q,Green MR,Grant S,Demo S,Choudhary GS,Sahu S,Agarwal B,Spodek M,Thiruthuvanathan V,Will B,Steidl U,Tippett GD,Burger J,Borthakur G,Jabbour E,Pemmaraju N,Kadia T,Kornblau S,Daver NG,Naqvi K,Short NJ, Garcia-Manero G
