Toxicity of Biologically Active Peptides and Future Safety Aspects: An Update
NPN 80078286. 60 vegan capsules
(Cambridge, MA: Academic Press), 131
10.1016/j.heliyon.2022.e09538 182 ZhaoW.ZhangL.XuY.ZhangZ.RenG.TangK.et al (2014)
Overexpressing of FZD7 activates the oncogenic factor tumor protein 63 (TP63), leading to increased levels of glutathione metabolic pathways, including GPX4, which protects cells against chemotherapy-induced oxidative stress and ferroptosis
In addition, some other members of SIRTs including SIRT3, 4 and 5 display neuroprotective roles against epilepsy as a result of evidences supporting the improvement of neuronal damage for SIRT3 via scavenging ROS in mitochondria [120], protection from excitotoxicity for SIRT4 via increasing GLT-1-mediated glutamate uptake [121] and reduction of hippocampal neurodegeneration and attenuation of seizure susceptibility for SIRT5 [122]