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The study used 36 male Sprague-Dawley rat pup, exposed to 250 mg/kg PPA to induce ASD-lke features, and pre-treated for 27 days with either yogurt, artichoke extract (400 mg/kg), luteolin (50 mg/kg) or Lacticaseibacillus rhamnosus GG (0.2 mL/day)

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Collectively, the gut microbiota dysbiosis mediated by these specific bacterial populations may jointly promote the occurrence and progression of OA through multiple pathways such as regulating the hosts immune-inflammatory response, metabolic disorders, and oxidative stress, providing novel targets and strategies based on gut microbiota regulation for the prevention and treatment of OA

Download figure Open in new tab Figure 2: In vivo GSH-edited and GABA+-edited spectra acquired from the SM1 (A, E, n=97), Thal (B, F, n=29), mPFC (C, G, n=43(GSH)/41(GABA)), and SMA (D, H, n=55(GSH)/56(GABA)) regions

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Acknowledgements This work was supported by the National Natural Science Foundation of China (grant # 81971256 [to HX]) and Natural Science Foundation of Guangdong Province (grant # 2016A030313067 [to HX])