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Four major PRR families have now been identified: Toll-like receptors (TLRs) and C-type lectin receptors, which are transmembrane proteins, and cytoplasmic retinoic acid-inducible gene (RIG-I)-like receptors (RLRs) and nucleotide oligomerization domain-like receptors (NLRs) (41)

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The clinical trial numbers reflect this progression clearly

This includes how long it will last, what theyll be doing, and whats expected of them

In an oncogenic context, the IGF family regulates a number of biological processes such as cancer cell proliferation, apoptosis, metabolism and protein synthesis, which are closely associated with the activation of PI3K/AKT signaling, which subsequently promotes the transcription of downstream pro-oncogenic target genes such as c-Myc and HIF-1 (77)

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