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Comparative performance of two quantitative safety signalling methods: implications for use in a pharmacovigilance department

US Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine

performed neuropsychological testing and analysis

Physiologically based pharmacokinetic (PBPK) models have been developed for exenatide (1 of 30), dulaglutide (1 of 30), semaglutide (1 of 30), and tirzepatide (2 of 30)

The blood sugar may not drop dangerously low (true hypoglycemia on tirzepatide monotherapy is rare), but even mild fluctuations can trigger the sympathetic nervous system enough to cause brief awakenings

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