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Mitochondrial biogenesis-associated proteins, particularly Nrf-1/2, act as transcription factors enhancing the expression of mitochondrial antioxidant genes (including manganese superoxide dismutase, catalase, peroxiredoxins 3 and 5, uncoupling protein 2, thioredoxin 2, and thioredoxin reductase), highlighting the antioxidant properties of mitochondrial biogenesis [94]

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bitot spots), causing dryness of the eyes, a condition called xerophthalmia