A 1200 mg/day ibuprofen dose (20 mg/kg/day, assuming an average human weight of 60 kg), would correspond to a treatment of 246.9 mg/kg/day in mice using the dose translation equation (Human equivalent dose (HED) = Animal Dose (mg/kg) Animal Km (3 for mouse)/Human Km (37 for human) 16
For instance, in the myocardium of exhaustive-exercised rats, TMZ produced specific cardioprotective outcomes by increasing GSH and GPX activity to clear oxidative stress
This is because the digestive system is a harsh environment
[DOI] [PMC free article] [PubMed] [Google Scholar] Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctt KL (2010) A meta-analysis of cytokines in major depression
Glutathione plays a key role in stimulating collagen synthesis by reducing free radicals that damage collagen-producing cells
AtOPT6 transports glutathione derivatives and is induced by primisulfuron