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Retatrutide is a triple-receptor agonist targeting GLP-1, GIP, and glucagon pathways simultaneously, producing an average of 24.2% body weight reduction in Phase 2 clinical trials at the 12mg dose

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Simo R, Guerci B, Schernthaner G, Gallwitz B, Rosas-Guzman J, Dotta F, Festa A, Zhou M, Kiljanski J

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The immediate effects are most pronounced in sports like weight lifting, cycling, and sprinting, where there is a more direct relationship between raw physical ability and results