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More interestingly, exogenous L -dopa/carbidopa could also greatly enhance the exposure of intracerebral GSH by upregulating GSH synthetases and enhancing homocysteine (HCY) levels in the striatum

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SOD, a critical endogenous antioxidant enzyme, mitigates oxidative stress by catalyzing the dismutation of superoxide radicals via redox cycling, thus maintaining redox homeostasis 67

Histamine intolerance is considered a subset of MCAS where too much histamine is released from mast cells, too much histamine is taken in by consuming histamine-containing foods, histamine is not broken down in the gut because of DAO gut enzyme deficiency, or not broken down in the liver because of HNMT deficiency