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Our group recently identified oxamic hydrazide as a potent CSE inhibitor by screening a large chemical library of 161,600 compounds ( 50 value of 13 M with high selectivity over other PLP-dependent enzymes including CBS, alanine aminotransferase and methionine -lyase

Cycling is another key strategy

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Proteins Struct Funct Bioinform 61:258271 Navien TN, Thevendran R, Hamdani HY et al (2021) In silico molecular docking in DNA aptamer development

It can suppress the levels of inflammation related mediators such as Th1, Th2, and pro-inflammatory cytokines which are the main cause in the development of diseases such as atopic dermatitis in the human body

Coordination with surgeon: Inform surgeon about peptide plans though expect skepticism