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Glucagon concentrations in plasma decreased under treatment with SAR425899 although the variability was high

The melanocortin system consists of melanocyte-stimulating hormone (MSH), ACTH, five G-protein coupled receptors (MR1R-MR5R), and endogenous antagonists (Agouti & Agouti-related proteins)

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Wakai K, Hayakawa N, Kojima M, Tamakoshi K, Watanabe Y, Suzuki K, Hashimoto S, Tokudome S, Toyoshima H, Ito Y, Tamakoshi A (2003) Smoking and colorectal cancer in a non-Western population: a prospective cohort study in Japan