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As a result, based on the limited research to date and methodological limitations, further research is warranted

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184,185 The close relationship between vitamin B 12 and folate can make it difficult to distinguish their independent deficiencies: B 12 deficiency causes a functional folate deficiency by trapping folate as 5-MTHF, thereby blocking homocysteine metabolism, because B 12 is required for the conversion into functional folate

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