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Overweight with comorbidities: Individuals with a BMI of 27 or higher who also have weight-related health conditions like type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea are also strong candidates

If reduced appetite from tirzepatide further decreases the small amount of B12-fortified foods these individuals consume, deficiency can develop rapidly

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On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes