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Retatrutide has not received marketing authorisation from the MHRA, EMA, or FDA and cannot be legally prescribed outside authorised clinical trials

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Wegovy and Ozempic are prescription medications that contain semaglutide, a GLP-1 receptor agonist, which works by helping regulate appetite, improve blood sugar control, and promote sustainable weight loss

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To reduce the effector functions mediated by the Fc fragment, researchers converted the antibody subtype to a non-glycosylated mouse IgG1 subtype by introducing an N297 to G mutation to achieve deglycosylation