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Altogether, muscle loss during GLP1RAs therapy is multifactorial, involving reduced protein intake and negative energy balance, hormonal adaptations, impaired mTOR signaling and protein synthesis, increased proteolysis and potential mitochondrial adaptations, and age, frailty, and physical inactivity as modifiers (Fig

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256,257 Individuals with specific genetic markers or microbiome signatures may respond differently to herbal interventions, which can be predicted using polygenic risk scores and single-nucleotide polymorphism (SNP)-based analyses