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Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig

Giambuzzi, A

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33 To date, the medical literature does not clearly demonstrate differential effects of short- versus long-acting GLP-1 RAs on small or large-bowel motility, as most pharmacodynamic differences appear to be confined to gastric emptying

Qiu et al., 2023

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