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Access this article Similar content being viewed by others References Aboud OA, Habib SL, Trott J et al (2017) Glutamine addiction in kidney cancer suppresses oxidative stress and can be exploited for real-time imaging

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Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20