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Discontinuing injections typically leads to appetite return and subsequent weight regain

PLoS ONE 10 , e0115563 (2015)

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Ipamorelin's research value largely derives from acting more narrowly within this system activating the GH-release arm of ghrelin signaling with substantially less spillover into the appetite, cortisol, and prolactin pathways that broader ghrelin-receptor activation, or older secretagogues like GHRP-6, tend to produce

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