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et al., 2025) (Figure 5)
Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants
TRIUMPH-4 (December 2025): Topline results from the Phase 3 TRIUMPH-4 investigational trial evaluating the triple hormone receptor agonist in adults with obesity or overweight and knee osteoarthritis, without diabetes, met all primary and key secondary endpoints, with substantial reductions in body weight and improvements in knee pain and physical function also observed
Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis (68)
Should liver enzymes be monitored during therapy