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It is currently available only within clinical trials, and any use outside a trial setting would be considered off-label and is not recommended
Measures like lower member cost-sharing for generics or penalties when someone insists on the brand despite a generic option being available can help steer utilization toward the cheaper product
Clinical evidence consistently demonstrates that patients regain approximately one-third of lost weight within the first year of stopping GLP-1 therapy, with longer-term studies suggesting even more substantial rebound [50]
Tirzepatide is a dual agonist, meaning it activates two hormone pathways: glucose-dependent insulinotropic polypeptide, or GIP, and glucagon-like peptide-1, or GLP-1
Preclinical Model: A non-human system used in research to study a biological phenomenon