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Vitamin B12 supports energy metabolism and may help reduce fatigue for some patients

Savic D, Hodson L, Neubauer S, et al

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These symptoms may be related to rapid weight loss, reduced muscle support, dehydration, increased physical activity, or an unrelated joint condition

Participants with BMI under 35 had higher dropout rates, sometimes due to perceived excessive weight loss. For participants with BMI 35 (the primary target population for this medication), discontinuation rates were 8.8-12.1%, more comparable to other weight loss medications