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The ventral tegmental area (VTA), the nucleus accumbens (NAc), and the prefrontal cortex (PFC) all contain GLP-1 receptors

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The derivation from native hGH provides biological plausibility: the C-terminal region of growth hormone has been known since the 1990s to possess independent lipolytic activity separate from the growth-promoting effects mediated by intact GH and IGF-1 signaling

Supports Cognitive Function Oxidative stress is a major contributor to neurodegenerative diseases like Alzheimers and Parkinsons

Kumar, K., Mehra, R., Guin, R

Abbreviations T2D: Type 2 diabetes SA: Sleep apnea GLP-1RAs: Glucagon-like peptide-1 receptor agonists LDSC: Linkage disequilibrium score regression MR: Mendelian Randomization IVW: Inverse-variance weighted GWAS: Genome-wide association study eQTL: Expression quantitative trait loci SNP: Single nucleotide polymorphism HbA1c: Glycated hemoglobin A1c OSA: Obstructive sleep apnea CSA: Central sleep apnea AHI: Apneahypopnea index NAFLD: Non-alcoholic fatty liver disease RCT: Randomized controlled trials IV: Instrumental variables References Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al