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The highest incidence occurs between the ages of 30 and 60

At approximately 0.69 per day, it sits at the premium end of the category

Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

The metabolism of catalpol in rats is mainly mediated by the intestinal microbiota, resulting in the formation of an aglycone-containing hemiacetal hydroxyl structure ( in vivo ( FIGURE 8 At present, the research field of catalpol has developed from the initial extraction and determination of active ingredients to the mechanism research of basic experiments, and then to the clinical research and new drug development in recent years, showing the transformation process from traditional Chinese medicine monomer to clinical application

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