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Description

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Exercise Mimetic Effects Research characterizing MOTS-c as an exercise-induced factor revealed: Elevation of circulating MOTS-c levels following acute exercise in humans Mimicry of exercise-induced metabolic adaptations when administered exogenously Enhanced oxidative metabolism similar to endurance training adaptations Improved muscle metabolic gene expression profiles Cardiovascular Research Cardiac Metabolic Function Studies in type 2 diabetes heart failure models demonstrated: Restoration of mitochondrial respiration in diabetic cardiomyocytes Improved cardiac contractile function through enhanced ATP production Protection against diabetes-induced cardiac dysfunction in mouse models Enhanced myocardial glucose utilization and metabolic flexibility Research using high-resolution respirometry showed MOTS-c treatment normalized mitochondrial oxygen consumption rates in diabetic hearts

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