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It is also worth noting that, in clinical practice, histamine intolerance and MCAS are frequently seen alongside other connective tissue conditions, including hypermobile Ehlers-Danlos syndrome (hEDS) and Postural Orthostatic Tachycardia Syndrome (POTS) a triad that overlaps significantly with lipoedema and warrants consideration in women presenting with complex, multisystem symptoms

Rather than indicating widespread metabolic disruption, the findings point to selective and potentially modifiable pathway-level alterations , consistent with the metabolic heterogeneity increasingly recognized in ASD

Liu, H., Colavitti, R., Rovira, I

At doses currently available, it is not