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doi: 10.1371/journal.pone.0058784 169 HansenHHFabriciusKBarkholtPNiehoffMLMorleyJEJelsingJet al

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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]