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Additionally, a reduction in liver enzyme levels was observed

Furthermore, hyperglycemia has been shown to enhance TXNIP expression by modulating histone acetylation and methylation processes (Paneni et al., 2012

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Taken together, these findings suggest that NSBSO-induced GSH depletion and synthesis inhibition can elevate intracellular ROS, thereby activating the caspase family, leading to GSDME cleavage and cell pyroptosis

Jorsal A, Kistorp C, Holmager P et al (2017) Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes ( LIVE )a multicentre, double-blind, randomised, placebo-controlled trial