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Conclusion A series linear Ang IV analogues demonstrating improved metabolic stability and very high affinity to IRAP have been reported, e.g., the potent hexapeptides 11 (AL-11) and 12 (IVDE77) with Ki values of 7.6 and 1.7 nM, respectively, data to be compared with the Ki value of Ang IV of 62 nM in the same binding assay

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This is where the sensory nerves travel (carrying migraine/headache/pain signals to the brain) and neuromuscular junctions lie (where the nerves that innervate and control the muscles enter the muscle)

Ricci G, Lo Bello M, Caccurri AM, Pastore A, Nuccetelli M, Parker MW, et al

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