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[4] Huber, H., Schieren, A., Holst, J

Since the primary, if not exclusive, source of GLP-1 in the CSF are brainstem GLP-1 neurons (and not GLP-1 from the circulation 3 ), this suggests that CSF-contacting neurons are regulated by the overall activity of brainstem GLP-1 neurons

Whether orally administered BPC-157 produces reliable systemic exposure in humans remains unclear

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Importantly, many of these challenges are now tractable using contemporary approaches to peptide engineering, receptor biology, and translational trial design