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However, the long-acting DAC form provides continuous rather than pulsatile stimulation, and the long-term consequences of losing GH's natural pulsatility are not well characterized in humans

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Zhang, Z., Yang, X., Song, Y.-Q

Clin Rev Allergy Immunol (2014) 47(2):13647

Y1-R-mediated effects on pancreatic islets Our experiments were also designed to determine whether peptides that are efficacious at lower concentrations and/or those that promote modified internalization/-arrestin recruitment might be capable of sustaining the beneficial effects beyond those currently observed while also reducing the frequency of adverse events