Exp Gerontol 108:166173 Aydin AF, Kusku-Kiraz Z, Dogru-Abbasoglu S et al (2010a) Effect of carnosine against thioacetamide-induced liver cirrhosis in rat
Identified hits from the shape similarity screening were ranked according to their ROCS combo score (Supplementary Table S5)
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Recent research determined that chronic alcohol intake inhibited the activation of mammalian target of rapamycin complex 1 (mTORC1), leading to an uncoupling status between lipolysis and the browning/thermogenesis of white adipose tissue (WAT), and thus exacerbating hepatic lipid accumulation, inflammation, and fibrosis in the development and progression of ALD (Song et al., 2023)
Fluorescence microscopy revealed increased levels of ROS (Figure S2J, K) and Fe 2+ (Figure S2L, M), and flow cytometry analysis revealed an increased level of LPO (Figure S2N, O) in the oe-ILF3+simvastatin group compared with that in the oe-ILF3 group
