Tesamorelin is FDAapproved for HIVassociated lipodystrophy, but this combination and its use for general body recomposition are offlabel and nonFDA-approved
Depending on the area and the amount of fat, multiple sessions may be required for optimal results
Many patients find their optimal balance well below the maximum and maintain excellent results there
New England Journal of Medicine , 387(24), 2245-2257
But without proper guidance, structure, and support, many people struggle with side effects, lose muscle instead of fat, regain weight after stopping medication, or don't achieve sustainable results
however, theoretical risks include off-target activation of the HGF/c-Met pathway, which is implicated in oncogenesis, warranting caution regarding long-term use