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The primary outcome was suicidality, which was defined as a composite of hospital admission for self-harm, suicidal ideation, or completed suicide

This is clearly the high end of expected - ~20% is expected via lifestyle intervention alone

Subcutaneous administration requires precision equipment

By mimicking the action of the glucagon-like peptide-1 hormone, Semaglutide GLP-1 enhances feelings of fullness and decreases hunger, facilitating a reduction in caloric intake and supporting sustainable weight loss

When appetite drops, patients may eat less food, drink less fluid, reduce fiber intake, or move less

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