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Additionally, there are important concerns regarding long-term safety

While celebrated, this rapid reduction in body fat, particularly subcutaneous fat, can impact skin integrity

Participants were randomized 2:1:1:1:1:2:2 to receive placebo or retatrutide at 1 mg, 4 mg (starting at 2 mg), 4 mg (starting at 4 mg), 8 mg (starting at 2 mg), 8 mg (starting at 4 mg), or 12 mg (starting at 2 mg) administered subcutaneously once weekly for 48 weeks

Theres limited research on this specific interaction, but doctors advise caution

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Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons