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Zhang X, Irajizad E, Hoffman KL, Fahrmann JF, Li F, Seo YD, Browman GJ, Dennison JB, Vykoukal J, Luna PN, Siu W, Wu R, Murage E, Ajami NJ, McQuade JL, Wargo JA, Long JP, Do KA, Lampe JW, Basen-Engquist KM, Okhuysen PC, Kopetz S , Hanash SM, Petrosino JF, Scheet P, Daniel CR

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Acceptable interventions include supervised diet programs, FDA-approved weight-loss medications (orlistat, phentermine-topiramate, naltrexone-bupropion), or bariatric counseling programs

In multiple mouse models, reducing dietary methionine inhibited tumor growth and boosted antitumor immunity by increasing the quantity and cytotoxicity of tumor-infiltrating CD8 + T cells