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Since people with cocaine use disorder suffer from depression, such comorbidity was evaluated using cocaine self-administration/extinction/reinstatement procedures in the rat model of depression based on the removal of the olfactory bulbs [19]

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One theory is that due to the association between increased abundance of hybrid Insulin/IGF-1 receptors on target human tissues and elevated plasma insulin observed in patients with hyperinsulinemia, that these hybrid IR receptors may cause insulin resistance in certain human tissues

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