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Lower doses produced more modest reductions: 4 mg dose: approximately 8.7% mean weight reduction 0.5 mg dose: approximately 2.0% mean weight reduction Placebo: a small mean weight gain of approximately 2.0% Readers should note that these figures are drawn from a single phase 2 trial with a relatively small sample size and 24-week duration

The focus is on dietary changes , physical activity, and oral medication

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Read PA, Khan FZ, Dutka DP: Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease

Those treated with an SGLT2i were more than twice as likely to develop a UTI or pyelonephritis than those treated with a GLP-1 RA (RR 2.27 [95% CI 1.12, 4.55] p =0.019)

Nanayakkara, N., Lh Huang, M., Jenkins, A