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In a study by Rotondo Dottore, G., it was mentioned that H2O2 has a dual effect on fibroblast cell proliferation, with low concentrations of H2O2 inducing proliferation and releasing cytokines, while high concentrations of H2O2 are cytotoxic, when cell viability decreases (9, 31)

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E., Warwick, W

Hypoxia of endothelial cells leads to MMP-2-dependent survival and death

Front Pharmacol 9 , 190 (2018)

Matrine protects against experimental autoimmune encephalomyelitis through modulating microglial ferroptosis