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For the pharmacological intervention in the chronic HUA experiment, 75 mice were randomly divided into five groups: the blank group, HUA model group, LC group, TMZ group and allopurinol (AP, Sigma, A8003) group

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We also identify that FSP1 can catalyze the production of H 2 O 2 and the conversion of FAD to 6-hydroxy-FAD in the presence of oxygen and NAD(P)H in vitro, and 6-hydroxy-FAD directly inhibits ferroptosis in cells

doi: 10.1007/s11906-018-0812-z