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Researchers modified the original peptide structure to create longer-acting formulations with various strategies: liraglutide (once daily) uses fatty acid albumin-binding, dulaglutide (once weekly) employs an Fc-fusion approach, exenatide extended-release (Bydureon, once weekly) utilises microsphere technology, and semaglutide (once weekly) incorporates fatty acid modifications

We report the crystal structures of cFSP1 (residues 12373, hereafter named cFSP1 N ) in its substrate-free and ubiquinone (CoQ 1 )-bound forms at 2.0 and 2.6 resolution (Supplementary Table 1), respectively

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GLP-1R downregulation can diminish the effects of GLP-1 and its analogues on target cells